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Risk Factors of Persistent Pulmonary Hypertension of Newborn (PPHN) in Different Gestation

Received: 14 June 2019     Accepted: 15 July 2019     Published: 12 August 2019
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Abstract

Persistent Pulmonary Hypertension of Newborn (PPHN) is a critical neonatal problem resulting from failed circulatory adaptation at birth, associated with substantial perinatal morbidity as well as mortality. Despite significant advancement in management of PPHN across the globe, it still remains a challenge especially in developing countries like Bangladesh. So the study was conducted over five years in United Hospital Limited to determine the risk factors of PPHN in relation to gestational age. All PPHN cases diagnosed by echocardiogram were included in the study and divided into term (≥ 37 wks) and preterm group (<37 wks). Among 157 of PPHN cases, 66% were male, 59% were preterm, mean gestational age and birth weight were 35.6 ± 2.54 wks and 2598.22 ± 760.353 gm respectively. Maternal asthma (p 0.01) and pre-eclamptic toxemia (p 0.010) were significant risk factors for persistent pulmonary hypertension of newborn. PPHN was found high in neonates with Respiratory Distress Syndrome (p 0.000) and Meconium Aspiration Syndrome (p 0.000). Most (96%) of the babies were discharged to home.

Published in American Journal of Pediatrics (Volume 5, Issue 3)
DOI 10.11648/j.ajp.20190503.20
Page(s) 142-147
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Persistent Pulmonary Hypertension, Risk Factors, Persistent Fetal Circulation

References
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Cite This Article
  • APA Style

    Nargis Ara Begum, Sharmin Afroze, Runa Laila, Shahnaz Parvin Siddiqua, Mohammad Toyobur Rahaman. (2019). Risk Factors of Persistent Pulmonary Hypertension of Newborn (PPHN) in Different Gestation. American Journal of Pediatrics, 5(3), 142-147. https://doi.org/10.11648/j.ajp.20190503.20

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    ACS Style

    Nargis Ara Begum; Sharmin Afroze; Runa Laila; Shahnaz Parvin Siddiqua; Mohammad Toyobur Rahaman. Risk Factors of Persistent Pulmonary Hypertension of Newborn (PPHN) in Different Gestation. Am. J. Pediatr. 2019, 5(3), 142-147. doi: 10.11648/j.ajp.20190503.20

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    AMA Style

    Nargis Ara Begum, Sharmin Afroze, Runa Laila, Shahnaz Parvin Siddiqua, Mohammad Toyobur Rahaman. Risk Factors of Persistent Pulmonary Hypertension of Newborn (PPHN) in Different Gestation. Am J Pediatr. 2019;5(3):142-147. doi: 10.11648/j.ajp.20190503.20

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  • @article{10.11648/j.ajp.20190503.20,
      author = {Nargis Ara Begum and Sharmin Afroze and Runa Laila and Shahnaz Parvin Siddiqua and Mohammad Toyobur Rahaman},
      title = {Risk Factors of Persistent Pulmonary Hypertension of Newborn (PPHN) in Different Gestation},
      journal = {American Journal of Pediatrics},
      volume = {5},
      number = {3},
      pages = {142-147},
      doi = {10.11648/j.ajp.20190503.20},
      url = {https://doi.org/10.11648/j.ajp.20190503.20},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20190503.20},
      abstract = {Persistent Pulmonary Hypertension of Newborn (PPHN) is a critical neonatal problem resulting from failed circulatory adaptation at birth, associated with substantial perinatal morbidity as well as mortality. Despite significant advancement in management of PPHN across the globe, it still remains a challenge especially in developing countries like Bangladesh. So the study was conducted over five years in United Hospital Limited to determine the risk factors of PPHN in relation to gestational age. All PPHN cases diagnosed by echocardiogram were included in the study and divided into term (≥ 37 wks) and preterm group (<37 wks). Among 157 of PPHN cases, 66% were male, 59% were preterm, mean gestational age and birth weight were 35.6 ± 2.54 wks and 2598.22 ± 760.353 gm respectively. Maternal asthma (p 0.01) and pre-eclamptic toxemia (p 0.010) were significant risk factors for persistent pulmonary hypertension of newborn. PPHN was found high in neonates with Respiratory Distress Syndrome (p 0.000) and Meconium Aspiration Syndrome (p 0.000). Most (96%) of the babies were discharged to home.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Risk Factors of Persistent Pulmonary Hypertension of Newborn (PPHN) in Different Gestation
    AU  - Nargis Ara Begum
    AU  - Sharmin Afroze
    AU  - Runa Laila
    AU  - Shahnaz Parvin Siddiqua
    AU  - Mohammad Toyobur Rahaman
    Y1  - 2019/08/12
    PY  - 2019
    N1  - https://doi.org/10.11648/j.ajp.20190503.20
    DO  - 10.11648/j.ajp.20190503.20
    T2  - American Journal of Pediatrics
    JF  - American Journal of Pediatrics
    JO  - American Journal of Pediatrics
    SP  - 142
    EP  - 147
    PB  - Science Publishing Group
    SN  - 2472-0909
    UR  - https://doi.org/10.11648/j.ajp.20190503.20
    AB  - Persistent Pulmonary Hypertension of Newborn (PPHN) is a critical neonatal problem resulting from failed circulatory adaptation at birth, associated with substantial perinatal morbidity as well as mortality. Despite significant advancement in management of PPHN across the globe, it still remains a challenge especially in developing countries like Bangladesh. So the study was conducted over five years in United Hospital Limited to determine the risk factors of PPHN in relation to gestational age. All PPHN cases diagnosed by echocardiogram were included in the study and divided into term (≥ 37 wks) and preterm group (<37 wks). Among 157 of PPHN cases, 66% were male, 59% were preterm, mean gestational age and birth weight were 35.6 ± 2.54 wks and 2598.22 ± 760.353 gm respectively. Maternal asthma (p 0.01) and pre-eclamptic toxemia (p 0.010) were significant risk factors for persistent pulmonary hypertension of newborn. PPHN was found high in neonates with Respiratory Distress Syndrome (p 0.000) and Meconium Aspiration Syndrome (p 0.000). Most (96%) of the babies were discharged to home.
    VL  - 5
    IS  - 3
    ER  - 

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Author Information
  • Department of Neonatology, United Hospital Limited, Dhaka, Bangladesh

  • Department of Neonatology, Dr. M R Khan Shishu (Children) Hospital & Institute of Child Health, Dhaka, Bangladesh

  • Department of Neonatology, United Hospital Limited, Dhaka, Bangladesh

  • Department of Neonatology, United Hospital Limited, Dhaka, Bangladesh

  • Department of Neonatology, United Hospital Limited, Dhaka, Bangladesh

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