| Peer-Reviewed

Clinical Profile of Dengue and Predictors of Its Severity Among Children

Received: 26 September 2019     Accepted: 14 October 2019     Published: 23 October 2019
Views:       Downloads:
Abstract

Dengue fever is a self-limiting, systemic viral illness that has a wide range of clinical manifestations. Last year dengue was severe in children with much mortality. This study was aimed to see the clinical profile of dengue and to find out the risk factors for developing severity. This cross sectional study was conducted over four months (June-September, 2018) in Department of Pediatrics of United Hospital Limited. All admitted dengue cases were analyzed. The predictors of developing severity were assessed by comparing variables between classical and severe dengue fever groups. A total of 106 children with Dengue fever were admitted. Mean age was 5.8±3 years with male predominance (60%). Common presentations include fever (100%), flushed appearance (72%), rash (43%), vomiting (39%), abdominal pain (36%), shock (28%) and respiratory distress (23%). In risk factor analysis, overweight (OR: 8.275, CI: 1.378-49.706) and massive serositis (OR: 17.86, CI: 4.733-67.399) were found statistically significant predictors of severe dengue. The overall mortality was 3%. So, overweight children and those patients who develop massive serositis are at increased risk of having severe dengue. Early identification of these features can help physicians to manage these cases judiciously.

Published in American Journal of Pediatrics (Volume 5, Issue 4)
DOI 10.11648/j.ajp.20190504.19
Page(s) 219-223
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Dengue in Children, Dengue Severity, Risk Factors of Dengue

References
[1] National Guideline for clinical management of Dengue syndrome. 4th edition, 2018.
[2] WHO fact sheets- Dengue and severe dengue. April 2019.
[3] Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL et.al. The global distribution and burden of dengue. Nature; 496: 504-507.
[4] Brady OJ, Gething PW, Bhatt S, Messina JP, Brownstein JS, Hoen AG et al. Refining the global spatial limits of dengue virus transmission by evidence-based consensus. PLoS Negl Trop Dis. 2012; 6: 1760.
[5] Alam S, Sadat S, Swapan Z, Ahmed A, Karim N, Paul HK, ZamanS. Clinical Profile of Dengue Fever in Children. Bangladesh J Child Health. 2009; 33 (2): 55-58.
[6] Dengue fever and dengue haemorrhagic fever. World Health Organization. 2009.
[7] Prevention and control of dengue and dengue hemorrhagic fever: comprehensive guidelines. World Health Organisation. 1999.
[8] CDC 2007. Center for Disease Control, CDC Health Center. Georgia, USA.
[9] Kalayanarooj S, Nimmannitiya S. Is dengue severity related to nutritional status? Southeast Asian J Trop Med. Public Health. 2005; 36: 378-84.
[10] Chuansumrit A, Puripokal C, Butthep P, WongtirapornW, Sasanakul W, Tangnararatchakit K, et al. Laboratory predictors of dengue shock syndrome during the febrile stage. Southeast Asian J Trop Med Public Health. 2010; 41: 326-32.
[11] Sutaryo. Dengue. Yogyakarta: MedicaFakultasKedokteran UGM; 2004.
[12] Tantracheewathorn T, Tantracheewathorn S. Risk factors of Dengue shock syndrome in children. J Med Assoc Thai. 2007; 90: 272-7.
[13] Islam TQ. Changing Epidemiological and Clinical pattern of Dengue inBangladesh 2018. J MEDICINE 2019; 20: 1-3.
[14] Rodhain F, Rosen L. Mosquito vectors and dengue virusvector relationships. In: Gubler DJ, Kuno G, editors. Dengueand Dengue Hemorrhagic Fever. New York: CAB. International; 1997; 45-60.
[15] Gubler DJ. The changing epidemiology of yellow fever anddengue, 1900 to 2003: Full circle? Comp ImmunolMicrobiolInfect Dis 2004; 27: 319-30.
[16] CDC BMI for age growth chart. Centers for Disease Control and Prevention. Factsheet 2018.
[17] Sarker A, Tara PHDAR d, Chatterjee S. Molecular typing of dengue virus circulating in Kolkata India in 2010. Journal of tropical medicine. 2012; 13.
[18] Ahmed FU, Mahmood BC, Sharma JD, Hoque SM, Zaman R, Hasan MS. Dengur and Dengue Haemorrhagic fever in Children during the 2000 outbreak in Chittagong, Bangladesh. Dengue Bulletin 2001; 25: 33-39.
[19] Mobarak MR, Islam R, Bhuiya AKM, Akand N, Begum F. Evaluation of Dengue Fever in a tertiary care children hospital of Bangladesh. Northern International Medical College Journal.2017; 9 (1): 274-277.
[20] Gupta E, Dar L, Kapoor G, Broor S the changing epidemiology of dengue in Delhi, India. Virology Journal. 2006; 5 (3): 1.
[21] Chakravarti a, Kumaria R. Eco-epidemiologycal analysis of dengue infection during an outbreak of dengue fever, India. Virology journal.2005; 14 (2): 1.
[22] Rahman M, Rahman K, Siddque AK, Shoma S, Kamal AH, Ali KS, et al. FirstOutbreak of Dengue Hemorrhagic Fever, Bangladesh. Emerg Infect Dis2002; 8: 738-40.
[23] Zulkipli MS, Dahlui M, Jamil NS, Peramalah D, CheeWai HV, Bulgiba A. The association between obesity and dengue severity among pediatric patients: A systematic review and meta- analysis. PlOSNegi Trop Dis. 2018. https://doi.org/10.1371/journal.pntd.0006263
[24] Juffrie M, Meer GM, Haasnoot K, Sutaryo, Veerman AJ, Thijs LG. Inflammatory mediators in dengue virus infection in children: Interleuki -6 and its relation to C-reactive protein and secretory phospholipase A2. Am J Trop Med Hyg. 2001; 65: 70-75.
Cite This Article
  • APA Style

    Sharmin Afroze, Salim Shakur, Abrar Wahab, Salomee Shakur. (2019). Clinical Profile of Dengue and Predictors of Its Severity Among Children. American Journal of Pediatrics, 5(4), 219-223. https://doi.org/10.11648/j.ajp.20190504.19

    Copy | Download

    ACS Style

    Sharmin Afroze; Salim Shakur; Abrar Wahab; Salomee Shakur. Clinical Profile of Dengue and Predictors of Its Severity Among Children. Am. J. Pediatr. 2019, 5(4), 219-223. doi: 10.11648/j.ajp.20190504.19

    Copy | Download

    AMA Style

    Sharmin Afroze, Salim Shakur, Abrar Wahab, Salomee Shakur. Clinical Profile of Dengue and Predictors of Its Severity Among Children. Am J Pediatr. 2019;5(4):219-223. doi: 10.11648/j.ajp.20190504.19

    Copy | Download

  • @article{10.11648/j.ajp.20190504.19,
      author = {Sharmin Afroze and Salim Shakur and Abrar Wahab and Salomee Shakur},
      title = {Clinical Profile of Dengue and Predictors of Its Severity Among Children},
      journal = {American Journal of Pediatrics},
      volume = {5},
      number = {4},
      pages = {219-223},
      doi = {10.11648/j.ajp.20190504.19},
      url = {https://doi.org/10.11648/j.ajp.20190504.19},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20190504.19},
      abstract = {Dengue fever is a self-limiting, systemic viral illness that has a wide range of clinical manifestations. Last year dengue was severe in children with much mortality. This study was aimed to see the clinical profile of dengue and to find out the risk factors for developing severity. This cross sectional study was conducted over four months (June-September, 2018) in Department of Pediatrics of United Hospital Limited. All admitted dengue cases were analyzed. The predictors of developing severity were assessed by comparing variables between classical and severe dengue fever groups. A total of 106 children with Dengue fever were admitted. Mean age was 5.8±3 years with male predominance (60%). Common presentations include fever (100%), flushed appearance (72%), rash (43%), vomiting (39%), abdominal pain (36%), shock (28%) and respiratory distress (23%). In risk factor analysis, overweight (OR: 8.275, CI: 1.378-49.706) and massive serositis (OR: 17.86, CI: 4.733-67.399) were found statistically significant predictors of severe dengue. The overall mortality was 3%. So, overweight children and those patients who develop massive serositis are at increased risk of having severe dengue. Early identification of these features can help physicians to manage these cases judiciously.},
     year = {2019}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Clinical Profile of Dengue and Predictors of Its Severity Among Children
    AU  - Sharmin Afroze
    AU  - Salim Shakur
    AU  - Abrar Wahab
    AU  - Salomee Shakur
    Y1  - 2019/10/23
    PY  - 2019
    N1  - https://doi.org/10.11648/j.ajp.20190504.19
    DO  - 10.11648/j.ajp.20190504.19
    T2  - American Journal of Pediatrics
    JF  - American Journal of Pediatrics
    JO  - American Journal of Pediatrics
    SP  - 219
    EP  - 223
    PB  - Science Publishing Group
    SN  - 2472-0909
    UR  - https://doi.org/10.11648/j.ajp.20190504.19
    AB  - Dengue fever is a self-limiting, systemic viral illness that has a wide range of clinical manifestations. Last year dengue was severe in children with much mortality. This study was aimed to see the clinical profile of dengue and to find out the risk factors for developing severity. This cross sectional study was conducted over four months (June-September, 2018) in Department of Pediatrics of United Hospital Limited. All admitted dengue cases were analyzed. The predictors of developing severity were assessed by comparing variables between classical and severe dengue fever groups. A total of 106 children with Dengue fever were admitted. Mean age was 5.8±3 years with male predominance (60%). Common presentations include fever (100%), flushed appearance (72%), rash (43%), vomiting (39%), abdominal pain (36%), shock (28%) and respiratory distress (23%). In risk factor analysis, overweight (OR: 8.275, CI: 1.378-49.706) and massive serositis (OR: 17.86, CI: 4.733-67.399) were found statistically significant predictors of severe dengue. The overall mortality was 3%. So, overweight children and those patients who develop massive serositis are at increased risk of having severe dengue. Early identification of these features can help physicians to manage these cases judiciously.
    VL  - 5
    IS  - 4
    ER  - 

    Copy | Download

Author Information
  • Department of Neonatology, Dr. M. R Khan Shishu Hospital & Institute of Child Health, Dhaka, Bangladesh

  • Department of Paediatrics, United Hospital Limited, Dhaka, Bangladesh

  • Department of Public Health, North South University, Dhaka, Bangladesh

  • Department of Medicine, Uttara Adhunic Medical College, Dhaka, Bangladesh

  • Sections