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Exploration of Vitamin D Supplementation Adjuvant Therapy for Childhood Asthma and the Best Treatment Options

Received: 12 November 2019     Accepted: 12 December 2019     Published: 24 December 2019
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Abstract

Vitamin D not only promotes the health of human bones and muscles but also has an important impact on the metabolism of extraskeletal tissues. As a steroid hormone, vitamin D possesses important physiological functions, including cell differentiation and proliferation and immune regulation. Research has shown that vitamin D insufficiency (VDI) or vitamin D deficiency (VDD) can make children susceptible to asthma. Vitamin D has important immunoregulatory functions associated with preventing the occurrence of asthma or the worsening of its symptoms, improving lung function and enhancing glucocorticoid (GCS) action. An increasing number of randomized controlled intervention studies have confirmed that vitamin D affects the occurrence and development of asthmatic diseases. In recent years, accumulating laboratory and clinical research has supported the use of vitamin D as an adjuvant treatment for asthma and has achieved good clinical results. But the clinical outcome of vitamin D in the treatment of asthma is not as impressive as experimental studies. In addition to the complexity of clinical research, it may be related to clinical application methods. In order to combine theory with clinical practice, focused on exploring and selecting the most effective vitamin D adjuvant treatment of asthma, and comprehensively optimizing and applying these methods is beneficial to improve the therapeutic effect. However, there are different opinions regarding the results of the studies.

Published in American Journal of Pediatrics (Volume 5, Issue 4)
DOI 10.11648/j.ajp.20190504.32
Page(s) 291-298
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Vitamin D, VDD, Asthma, Children, Vitamin D Adjuvant Therapy

References
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  • APA Style

    Zhendong Yang, Xuding Sun, Jihong Wu, Gaojun Zhou, Yingyang Xu, et al. (2019). Exploration of Vitamin D Supplementation Adjuvant Therapy for Childhood Asthma and the Best Treatment Options. American Journal of Pediatrics, 5(4), 291-298. https://doi.org/10.11648/j.ajp.20190504.32

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    ACS Style

    Zhendong Yang; Xuding Sun; Jihong Wu; Gaojun Zhou; Yingyang Xu, et al. Exploration of Vitamin D Supplementation Adjuvant Therapy for Childhood Asthma and the Best Treatment Options. Am. J. Pediatr. 2019, 5(4), 291-298. doi: 10.11648/j.ajp.20190504.32

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    AMA Style

    Zhendong Yang, Xuding Sun, Jihong Wu, Gaojun Zhou, Yingyang Xu, et al. Exploration of Vitamin D Supplementation Adjuvant Therapy for Childhood Asthma and the Best Treatment Options. Am J Pediatr. 2019;5(4):291-298. doi: 10.11648/j.ajp.20190504.32

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  • @article{10.11648/j.ajp.20190504.32,
      author = {Zhendong Yang and Xuding Sun and Jihong Wu and Gaojun Zhou and Yingyang Xu and Xiong Xie and Kai Guan},
      title = {Exploration of Vitamin D Supplementation Adjuvant Therapy for Childhood Asthma and the Best Treatment Options},
      journal = {American Journal of Pediatrics},
      volume = {5},
      number = {4},
      pages = {291-298},
      doi = {10.11648/j.ajp.20190504.32},
      url = {https://doi.org/10.11648/j.ajp.20190504.32},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20190504.32},
      abstract = {Vitamin D not only promotes the health of human bones and muscles but also has an important impact on the metabolism of extraskeletal tissues. As a steroid hormone, vitamin D possesses important physiological functions, including cell differentiation and proliferation and immune regulation. Research has shown that vitamin D insufficiency (VDI) or vitamin D deficiency (VDD) can make children susceptible to asthma. Vitamin D has important immunoregulatory functions associated with preventing the occurrence of asthma or the worsening of its symptoms, improving lung function and enhancing glucocorticoid (GCS) action. An increasing number of randomized controlled intervention studies have confirmed that vitamin D affects the occurrence and development of asthmatic diseases. In recent years, accumulating laboratory and clinical research has supported the use of vitamin D as an adjuvant treatment for asthma and has achieved good clinical results. But the clinical outcome of vitamin D in the treatment of asthma is not as impressive as experimental studies. In addition to the complexity of clinical research, it may be related to clinical application methods. In order to combine theory with clinical practice, focused on exploring and selecting the most effective vitamin D adjuvant treatment of asthma, and comprehensively optimizing and applying these methods is beneficial to improve the therapeutic effect. However, there are different opinions regarding the results of the studies.},
     year = {2019}
    }
    

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    T1  - Exploration of Vitamin D Supplementation Adjuvant Therapy for Childhood Asthma and the Best Treatment Options
    AU  - Zhendong Yang
    AU  - Xuding Sun
    AU  - Jihong Wu
    AU  - Gaojun Zhou
    AU  - Yingyang Xu
    AU  - Xiong Xie
    AU  - Kai Guan
    Y1  - 2019/12/24
    PY  - 2019
    N1  - https://doi.org/10.11648/j.ajp.20190504.32
    DO  - 10.11648/j.ajp.20190504.32
    T2  - American Journal of Pediatrics
    JF  - American Journal of Pediatrics
    JO  - American Journal of Pediatrics
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    EP  - 298
    PB  - Science Publishing Group
    SN  - 2472-0909
    UR  - https://doi.org/10.11648/j.ajp.20190504.32
    AB  - Vitamin D not only promotes the health of human bones and muscles but also has an important impact on the metabolism of extraskeletal tissues. As a steroid hormone, vitamin D possesses important physiological functions, including cell differentiation and proliferation and immune regulation. Research has shown that vitamin D insufficiency (VDI) or vitamin D deficiency (VDD) can make children susceptible to asthma. Vitamin D has important immunoregulatory functions associated with preventing the occurrence of asthma or the worsening of its symptoms, improving lung function and enhancing glucocorticoid (GCS) action. An increasing number of randomized controlled intervention studies have confirmed that vitamin D affects the occurrence and development of asthmatic diseases. In recent years, accumulating laboratory and clinical research has supported the use of vitamin D as an adjuvant treatment for asthma and has achieved good clinical results. But the clinical outcome of vitamin D in the treatment of asthma is not as impressive as experimental studies. In addition to the complexity of clinical research, it may be related to clinical application methods. In order to combine theory with clinical practice, focused on exploring and selecting the most effective vitamin D adjuvant treatment of asthma, and comprehensively optimizing and applying these methods is beneficial to improve the therapeutic effect. However, there are different opinions regarding the results of the studies.
    VL  - 5
    IS  - 4
    ER  - 

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Author Information
  • Department of Respiratory Asthma, Beijing Jingdu Children's Hospital, Beijing, China

  • Department of Respiratory Asthma, Beijing Jingdu Children's Hospital, Beijing, China

  • Department of Respiratory Asthma, Beijing Jingdu Children's Hospital, Beijing, China

  • Department of Respiratory Asthma, Beijing Jingdu Children's Hospital, Beijing, China

  • Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

  • Department of Pediatrics, Third Clinical Medical College of Three Gorges University (Gezhouba Central Hospital), Yichang, China

  • Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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