| Peer-Reviewed

Hypoglycaemia in the Early Neonatal Period in Newborns

Received: 23 January 2021     Accepted: 22 April 2021     Published: 28 January 2022
Views:       Downloads:
Abstract

Neonatal hypoglycaemia is a topical problem in neonatology and paediatric endocrinology. In recent years, problems of glycaemia monitoring during first days of life have been discussed as well as the strategy for management of newborns with the syndrome of hypoglycemia and evaluation of metabolism in brain neurons has been a matter of scientific research. Scientific publications regarding the detection rate and duration of low glucose values in the early neonatal period as well as means of their correction and conducted therapy results are very scarce and ambiguous, which determines the necessity of new modern data regarding the problem considered. Purpose of the study: to study the detection rate and dynamics of clinical and laboratory manifestations of hypoglycaemia in children in the early neonatal period in order to optimise observation of newborns at the risk of developing this condition. Materials and methods: an open, retrospective, continuous, single-centre study was conducted to obtain preliminary data important for development of monitoring strategies for newborns at the risk of hypoglycaemia (neonates with high birth weight, children born to mothers with diabetes, newborns with intrauterine growth restriction). The target studied group was constituted by 522 newborns of both genders in the early neonatal period (aged 0 to 7 days). Results: the paper presents data on hypoglycaemia detection rate in newborns with risk factors for hypoglycaemia development, clinical and laboratory features of this condition, dynamics of glycaemia during the early neonatal period as well as the timing of blood glucose stabilisation (the age of normoglycaemia achievement).

Published in American Journal of Pediatrics (Volume 8, Issue 1)
DOI 10.11648/j.ajp.20220801.15
Page(s) 17-22
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Newborns, Diabetic Fetopathy, Hypoglycemia in Newborns, Intrauterine Growth Restriction, High Birth Weight

References
[1] Taranushenko T. E., Kiseleva N. G., Lazareva O. V., Kalyuzhnaya I.I. Hypoglycemia in newborns: literature review and case report. Endocrinology problems. 2019; 65: (4): 251-262 (in Russ). doi: 10.14341/probl8336.
[2] Qiao L. X., Wang J., Yan J. H., Xu S. X., Wang H., Zhu W. Y., Zhang H. Y., Li J., Feng X. Follow-up study of neurodevelopment in 2-year-old infants who had suffered from neonatal hypoglycemia. BMC Pediatr. 2019; 19 (1): 133. doi: 10.1186/s12887-019-1509-4.
[3] Chappe M. K. Hypoglycemia in High-Risk Infants Within the Immediate Postnatal Period. Neonatal Netw. 2020; 39 (5): 263-267. doi: 10.1891/0730-0832.39.5.263.
[4] Edwards T., Harding J. E. Clinical Aspects of Neonatal Hypoglycemia: A Mini Review. Front Pediatr. 2021; 8: 562251. doi: 10.3389/fped.2020.562251.
[5] Gu M. H., Amanda F., Yuan T. M. Brain Injury in Neonatal Hypoglycemia: A Hospital-Based Cohort Study. Clin Med Insights Pediatr. 2019; 13: 1179556519867953. doi: 10.1177/1179556519867953.
[6] Volodin N. N. Neonatology: a national guide. Short edition. M.: GEOTAR-Media, 2019; 896 (in Russ).
[7] Casertano A., Rossi A., Fecarotta S., Rosanio F. M., Moracas C., Di Candia F., Parenti G., Franzese A., Mozzillo E. An Overview of Hypoglycemia in Children Including a Comprehensive Practical Diagnostic Flowchart for Clinical Use. Front Endocrinol (Lausanne). 2021; 12: 684011. doi: 10.3389/fendo.2021.684011.
[8] Finken M. J. J., van der Steen M., Smeets C. C. J., Walenkamp M. J. E., de Bruin C., Hokken-Koelega A. C. S., Wit J. M. Children Born Small for Gestational Age: Differential Diagnosis, Molecular Genetic Evaluation, and Implications. Endocr Rev. 2018; 39 (6): 851-894. doi: 10.1210/er.2018-00083. Erratum in: Endocr Rev. 2019; 40 (1): 96.
[9] Queensland Clinical Guideline Supplement: Hypoglycaemia–newborn, 2019; 18.
[10] Barrero-Castillero A., Mao W., Stark A. R., Miedema D., Pursley D. M., Burris H. H. Glucose concentrations in enterally fed preterm infants. J Perinatol. 2020; 40 (12): 1834-1840. doi: 10.1038/s41372-020-0754-6.
[11] Gou B. H., Guan H. M., Bi Y. X., Ding B. J. Gestational diabetes: weight gain during pregnancy and its relationship to pregnancy outcomes. Chin Med J (Engl). 2019; 132 (2): 154-160. doi: 10.1097/CM9.0000000000000036.
[12] Abramowski A., Ward R., Hamdan A. H. Neonatal Hypoglycemia. 2021 Sep 9. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 30725790.
[13] Ornoy A., Becker M., Weinstein-Fudim L., Ergaz Z. Diabetes during Pregnancy: A Maternal Disease Complicating the Course of Pregnancy with Long-Term Deleterious Effects on the Offspring. A Clinical Review. Int J Mol Sci. 2021; 22 (6): 2965. doi: 10.3390/ijms22062965.
[14] De Angelis L. C., Brigati G., Polleri G., Malova M., Parodi A., Minghetti D., Rossi A., Massirio P., Traggiai C., Maghnie M., Ramenghi L. A. Neonatal Hypoglycemia and Brain Vulnerability. Front Endocrinol (Lausanne). 2021; 12: 634305. doi: 10.3389/fendo.2021.634305.
[15] Narvey M. R., Marks S. D. The screening and management of newborns at risk for low blood glucose. Paediatr Child Health. 2019; 24 (8): 536-554. doi: 10.1093/pch/pxz134.
[16] Saw C., Tan J E. A., Srinivasjois R. Risk Factors for Hypoglycaemia with Hypothermia in Neonates: An Audit in a Level II Special Care. Nursery. Pediatr Ther. 2021; 10 (379): 1-5.
Cite This Article
  • APA Style

    Tatyana E. Taranushenko, Ekaterina V. Antsiferova, Natalia G. Kiseleva. (2022). Hypoglycaemia in the Early Neonatal Period in Newborns. American Journal of Pediatrics, 8(1), 17-22. https://doi.org/10.11648/j.ajp.20220801.15

    Copy | Download

    ACS Style

    Tatyana E. Taranushenko; Ekaterina V. Antsiferova; Natalia G. Kiseleva. Hypoglycaemia in the Early Neonatal Period in Newborns. Am. J. Pediatr. 2022, 8(1), 17-22. doi: 10.11648/j.ajp.20220801.15

    Copy | Download

    AMA Style

    Tatyana E. Taranushenko, Ekaterina V. Antsiferova, Natalia G. Kiseleva. Hypoglycaemia in the Early Neonatal Period in Newborns. Am J Pediatr. 2022;8(1):17-22. doi: 10.11648/j.ajp.20220801.15

    Copy | Download

  • @article{10.11648/j.ajp.20220801.15,
      author = {Tatyana E. Taranushenko and Ekaterina V. Antsiferova and Natalia G. Kiseleva},
      title = {Hypoglycaemia in the Early Neonatal Period in Newborns},
      journal = {American Journal of Pediatrics},
      volume = {8},
      number = {1},
      pages = {17-22},
      doi = {10.11648/j.ajp.20220801.15},
      url = {https://doi.org/10.11648/j.ajp.20220801.15},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20220801.15},
      abstract = {Neonatal hypoglycaemia is a topical problem in neonatology and paediatric endocrinology. In recent years, problems of glycaemia monitoring during first days of life have been discussed as well as the strategy for management of newborns with the syndrome of hypoglycemia and evaluation of metabolism in brain neurons has been a matter of scientific research. Scientific publications regarding the detection rate and duration of low glucose values in the early neonatal period as well as means of their correction and conducted therapy results are very scarce and ambiguous, which determines the necessity of new modern data regarding the problem considered. Purpose of the study: to study the detection rate and dynamics of clinical and laboratory manifestations of hypoglycaemia in children in the early neonatal period in order to optimise observation of newborns at the risk of developing this condition. Materials and methods: an open, retrospective, continuous, single-centre study was conducted to obtain preliminary data important for development of monitoring strategies for newborns at the risk of hypoglycaemia (neonates with high birth weight, children born to mothers with diabetes, newborns with intrauterine growth restriction). The target studied group was constituted by 522 newborns of both genders in the early neonatal period (aged 0 to 7 days). Results: the paper presents data on hypoglycaemia detection rate in newborns with risk factors for hypoglycaemia development, clinical and laboratory features of this condition, dynamics of glycaemia during the early neonatal period as well as the timing of blood glucose stabilisation (the age of normoglycaemia achievement).},
     year = {2022}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Hypoglycaemia in the Early Neonatal Period in Newborns
    AU  - Tatyana E. Taranushenko
    AU  - Ekaterina V. Antsiferova
    AU  - Natalia G. Kiseleva
    Y1  - 2022/01/28
    PY  - 2022
    N1  - https://doi.org/10.11648/j.ajp.20220801.15
    DO  - 10.11648/j.ajp.20220801.15
    T2  - American Journal of Pediatrics
    JF  - American Journal of Pediatrics
    JO  - American Journal of Pediatrics
    SP  - 17
    EP  - 22
    PB  - Science Publishing Group
    SN  - 2472-0909
    UR  - https://doi.org/10.11648/j.ajp.20220801.15
    AB  - Neonatal hypoglycaemia is a topical problem in neonatology and paediatric endocrinology. In recent years, problems of glycaemia monitoring during first days of life have been discussed as well as the strategy for management of newborns with the syndrome of hypoglycemia and evaluation of metabolism in brain neurons has been a matter of scientific research. Scientific publications regarding the detection rate and duration of low glucose values in the early neonatal period as well as means of their correction and conducted therapy results are very scarce and ambiguous, which determines the necessity of new modern data regarding the problem considered. Purpose of the study: to study the detection rate and dynamics of clinical and laboratory manifestations of hypoglycaemia in children in the early neonatal period in order to optimise observation of newborns at the risk of developing this condition. Materials and methods: an open, retrospective, continuous, single-centre study was conducted to obtain preliminary data important for development of monitoring strategies for newborns at the risk of hypoglycaemia (neonates with high birth weight, children born to mothers with diabetes, newborns with intrauterine growth restriction). The target studied group was constituted by 522 newborns of both genders in the early neonatal period (aged 0 to 7 days). Results: the paper presents data on hypoglycaemia detection rate in newborns with risk factors for hypoglycaemia development, clinical and laboratory features of this condition, dynamics of glycaemia during the early neonatal period as well as the timing of blood glucose stabilisation (the age of normoglycaemia achievement).
    VL  - 8
    IS  - 1
    ER  - 

    Copy | Download

Author Information
  • Department of Pediatrics of Institute of Postgraduate Education, Krasnoyarsk State Medical University Named After Prof. Voino-Yasenetsky, Institute of Postgraduate Education for Pediatricians and Neonatologists, Krasnoyarsk, Russia

  • Department of Pediatrics of Institute of Postgraduate Education, Krasnoyarsk State Medical University Named After Prof. Voino-Yasenetsky, Institute of Postgraduate Education for Pediatricians and Neonatologists, Krasnoyarsk, Russia

  • Department of Pediatrics of Institute of Postgraduate Education, Krasnoyarsk State Medical University Named After Prof. Voino-Yasenetsky, Institute of Postgraduate Education for Pediatricians and Neonatologists, Krasnoyarsk, Russia

  • Sections