Prematurity Combined with Parental Risk Factors Increase the Number of Intestinal Perforations: A Case Control Study

Melanie Kapapa; Janina Hahne; Alexandre Serra

doi:doi:10.11648/j.ajp.20220804.20

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Prematurity Combined with Parental Risk Factors Increase the Number of Intestinal Perforations: A Case Control Study

Melanie Kapapa, Janina Hahne, Alexandre Serra

Published in American Journal of Pediatrics (Volume 8, Issue 4)

Received: 27 September 2022 Accepted: 25 October 2022 Published: 23 November 2022

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Abstract

Background: Survival in preterm infants is strongly related to the occurrence of necrotizing enterocolitis (NEC) with intestinal perforation (NECp) compared to preterm with a focal intestinal perforation (FIP). Objective: The aim of this study was to elicit potential parental risk factors through a detailed maternal medical history and a comprehensive family history. Methods: A case-control design was used to compare both maternal medical history, factors such as drug use, individual lifestyle habits and external risk factors using standardized antenatal based questionnaires. The survey is completed by an interview with the participating parents of NEC, NECp, FIP and the control group (CG). Approval was granted by the local ethics committee (no. 13/15). Results: NEC/NECp mothers took more contraceptives (p=0.001), paracetamol (p=0.004), iodide (p=0.05) and calcium (p=0.04) and suffered from placental abruption (p=0.047), while fathers smoked more cigarettes/d (p=0.049). FIP mothers suffered from prolapsing amniotic sac (p=0.028) and alcohol consumption (p=0.034). NECp/ FIP mothers took more antibiotics (p<0.001). NEC/ FIP mothers were more likely to have uterine isthmus insufficiency (p=0.042). Conclusion: The accumulation of external factors such as alcohol consumption and passive nicotine use, the use of antibiotics and oral contraceptives together with pregnancy-associated maternal factors such as placental abruption and uterine isthmus insufficiency leads to higher rates of intestinal perforation in preterm infants.

Published in	American Journal of Pediatrics (Volume 8, Issue 4)
DOI	10.11648/j.ajp.20220804.20
Page(s)	252-257
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Risk Factor, Necrotizing Enterocolitis, Focal Intestinal Perforation, Preterm, Bowel Perforation

References

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APA Style

Melanie Kapapa, Janina Hahne, Alexandre Serra. (2022). Prematurity Combined with Parental Risk Factors Increase the Number of Intestinal Perforations: A Case Control Study. American Journal of Pediatrics, 8(4), 252-257. https://doi.org/10.11648/j.ajp.20220804.20

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ACS Style

Melanie Kapapa; Janina Hahne; Alexandre Serra. Prematurity Combined with Parental Risk Factors Increase the Number of Intestinal Perforations: A Case Control Study. Am. J. Pediatr. 2022, 8(4), 252-257. doi: 10.11648/j.ajp.20220804.20

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AMA Style

Melanie Kapapa, Janina Hahne, Alexandre Serra. Prematurity Combined with Parental Risk Factors Increase the Number of Intestinal Perforations: A Case Control Study. Am J Pediatr. 2022;8(4):252-257. doi: 10.11648/j.ajp.20220804.20

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@article{10.11648/j.ajp.20220804.20,
  author = {Melanie Kapapa and Janina Hahne and Alexandre Serra},
  title = {Prematurity Combined with Parental Risk Factors Increase the Number of Intestinal Perforations: A Case Control Study},
  journal = {American Journal of Pediatrics},
  volume = {8},
  number = {4},
  pages = {252-257},
  doi = {10.11648/j.ajp.20220804.20},
  url = {https://doi.org/10.11648/j.ajp.20220804.20},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20220804.20},
  abstract = {Background: Survival in preterm infants is strongly related to the occurrence of necrotizing enterocolitis (NEC) with intestinal perforation (NECp) compared to preterm with a focal intestinal perforation (FIP). Objective: The aim of this study was to elicit potential parental risk factors through a detailed maternal medical history and a comprehensive family history. Methods: A case-control design was used to compare both maternal medical history, factors such as drug use, individual lifestyle habits and external risk factors using standardized antenatal based questionnaires. The survey is completed by an interview with the participating parents of NEC, NECp, FIP and the control group (CG). Approval was granted by the local ethics committee (no. 13/15). Results: NEC/NECp mothers took more contraceptives (p=0.001), paracetamol (p=0.004), iodide (p=0.05) and calcium (p=0.04) and suffered from placental abruption (p=0.047), while fathers smoked more cigarettes/d (p=0.049). FIP mothers suffered from prolapsing amniotic sac (p=0.028) and alcohol consumption (p=0.034). NECp/ FIP mothers took more antibiotics (p<0.001). NEC/ FIP mothers were more likely to have uterine isthmus insufficiency (p=0.042). Conclusion: The accumulation of external factors such as alcohol consumption and passive nicotine use, the use of antibiotics and oral contraceptives together with pregnancy-associated maternal factors such as placental abruption and uterine isthmus insufficiency leads to higher rates of intestinal perforation in preterm infants.},
 year = {2022}
}

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TY  - JOUR
T1  - Prematurity Combined with Parental Risk Factors Increase the Number of Intestinal Perforations: A Case Control Study
AU  - Melanie Kapapa
AU  - Janina Hahne
AU  - Alexandre Serra
Y1  - 2022/11/23
PY  - 2022
N1  - https://doi.org/10.11648/j.ajp.20220804.20
DO  - 10.11648/j.ajp.20220804.20
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 252
EP  - 257
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20220804.20
AB  - Background: Survival in preterm infants is strongly related to the occurrence of necrotizing enterocolitis (NEC) with intestinal perforation (NECp) compared to preterm with a focal intestinal perforation (FIP). Objective: The aim of this study was to elicit potential parental risk factors through a detailed maternal medical history and a comprehensive family history. Methods: A case-control design was used to compare both maternal medical history, factors such as drug use, individual lifestyle habits and external risk factors using standardized antenatal based questionnaires. The survey is completed by an interview with the participating parents of NEC, NECp, FIP and the control group (CG). Approval was granted by the local ethics committee (no. 13/15). Results: NEC/NECp mothers took more contraceptives (p=0.001), paracetamol (p=0.004), iodide (p=0.05) and calcium (p=0.04) and suffered from placental abruption (p=0.047), while fathers smoked more cigarettes/d (p=0.049). FIP mothers suffered from prolapsing amniotic sac (p=0.028) and alcohol consumption (p=0.034). NECp/ FIP mothers took more antibiotics (p<0.001). NEC/ FIP mothers were more likely to have uterine isthmus insufficiency (p=0.042). Conclusion: The accumulation of external factors such as alcohol consumption and passive nicotine use, the use of antibiotics and oral contraceptives together with pregnancy-associated maternal factors such as placental abruption and uterine isthmus insufficiency leads to higher rates of intestinal perforation in preterm infants.
VL  - 8
IS  - 4
ER  -

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Author Information

Melanie Kapapa

Department of Surgery, Division of Pediatric Surgery, University Hospital, Ulm, Germany
Janina Hahne

Department of Paediatric and Adolescent Medicine, University Hospital, Ulm, Germany
Alexandre Serra

Department of Surgery, Division of Pediatric Surgery, University Hospital, Ulm, Germany

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APA Style

Melanie Kapapa, Janina Hahne, Alexandre Serra. (2022). Prematurity Combined with Parental Risk Factors Increase the Number of Intestinal Perforations: A Case Control Study. American Journal of Pediatrics, 8(4), 252-257. https://doi.org/10.11648/j.ajp.20220804.20

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ACS Style

Melanie Kapapa; Janina Hahne; Alexandre Serra. Prematurity Combined with Parental Risk Factors Increase the Number of Intestinal Perforations: A Case Control Study. Am. J. Pediatr. 2022, 8(4), 252-257. doi: 10.11648/j.ajp.20220804.20

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AMA Style

Melanie Kapapa, Janina Hahne, Alexandre Serra. Prematurity Combined with Parental Risk Factors Increase the Number of Intestinal Perforations: A Case Control Study. Am J Pediatr. 2022;8(4):252-257. doi: 10.11648/j.ajp.20220804.20

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@article{10.11648/j.ajp.20220804.20,
  author = {Melanie Kapapa and Janina Hahne and Alexandre Serra},
  title = {Prematurity Combined with Parental Risk Factors Increase the Number of Intestinal Perforations: A Case Control Study},
  journal = {American Journal of Pediatrics},
  volume = {8},
  number = {4},
  pages = {252-257},
  doi = {10.11648/j.ajp.20220804.20},
  url = {https://doi.org/10.11648/j.ajp.20220804.20},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20220804.20},
  abstract = {Background: Survival in preterm infants is strongly related to the occurrence of necrotizing enterocolitis (NEC) with intestinal perforation (NECp) compared to preterm with a focal intestinal perforation (FIP). Objective: The aim of this study was to elicit potential parental risk factors through a detailed maternal medical history and a comprehensive family history. Methods: A case-control design was used to compare both maternal medical history, factors such as drug use, individual lifestyle habits and external risk factors using standardized antenatal based questionnaires. The survey is completed by an interview with the participating parents of NEC, NECp, FIP and the control group (CG). Approval was granted by the local ethics committee (no. 13/15). Results: NEC/NECp mothers took more contraceptives (p=0.001), paracetamol (p=0.004), iodide (p=0.05) and calcium (p=0.04) and suffered from placental abruption (p=0.047), while fathers smoked more cigarettes/d (p=0.049). FIP mothers suffered from prolapsing amniotic sac (p=0.028) and alcohol consumption (p=0.034). NECp/ FIP mothers took more antibiotics (p<0.001). NEC/ FIP mothers were more likely to have uterine isthmus insufficiency (p=0.042). Conclusion: The accumulation of external factors such as alcohol consumption and passive nicotine use, the use of antibiotics and oral contraceptives together with pregnancy-associated maternal factors such as placental abruption and uterine isthmus insufficiency leads to higher rates of intestinal perforation in preterm infants.},
 year = {2022}
}

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TY  - JOUR
T1  - Prematurity Combined with Parental Risk Factors Increase the Number of Intestinal Perforations: A Case Control Study
AU  - Melanie Kapapa
AU  - Janina Hahne
AU  - Alexandre Serra
Y1  - 2022/11/23
PY  - 2022
N1  - https://doi.org/10.11648/j.ajp.20220804.20
DO  - 10.11648/j.ajp.20220804.20
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 252
EP  - 257
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20220804.20
AB  - Background: Survival in preterm infants is strongly related to the occurrence of necrotizing enterocolitis (NEC) with intestinal perforation (NECp) compared to preterm with a focal intestinal perforation (FIP). Objective: The aim of this study was to elicit potential parental risk factors through a detailed maternal medical history and a comprehensive family history. Methods: A case-control design was used to compare both maternal medical history, factors such as drug use, individual lifestyle habits and external risk factors using standardized antenatal based questionnaires. The survey is completed by an interview with the participating parents of NEC, NECp, FIP and the control group (CG). Approval was granted by the local ethics committee (no. 13/15). Results: NEC/NECp mothers took more contraceptives (p=0.001), paracetamol (p=0.004), iodide (p=0.05) and calcium (p=0.04) and suffered from placental abruption (p=0.047), while fathers smoked more cigarettes/d (p=0.049). FIP mothers suffered from prolapsing amniotic sac (p=0.028) and alcohol consumption (p=0.034). NECp/ FIP mothers took more antibiotics (p<0.001). NEC/ FIP mothers were more likely to have uterine isthmus insufficiency (p=0.042). Conclusion: The accumulation of external factors such as alcohol consumption and passive nicotine use, the use of antibiotics and oral contraceptives together with pregnancy-associated maternal factors such as placental abruption and uterine isthmus insufficiency leads to higher rates of intestinal perforation in preterm infants.
VL  - 8
IS  - 4
ER  -

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